Invitrogen™ PATE3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA576081

Product Code. 15972605

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

PATE3 (prostate and testis expressed protein 3), also known as PATE-DJ or HEL-127, is a 98 amino acid protein that contains one UPAR/Ly6 domain and belongs to the PATE family. PATE3 is a secreted protein that is expressed in prostate and testis. The gene that encodes PATE3 consists of around 3,490 bases and maps to human chromosome 11p15.5. Chromosome 11, which comprises approximately 4% of the human genome, is considered a gene and disease association-dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.

Specifications

• Antigen: PATE3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PATE3
• Gene Alias: Acrosomal vesicle protein HEL-127; epididymis-specific ESC112; Gm17365; HEL-127; Pate3; PATE-DJ; PATE-like protein DJ; predicted gene, 17365; prostate and testis expressed 3; prostate and testis expressed DJ; prostate and testis expressed protein 3; secreted TFP/Ly-6/uPAR protein PATE-DJ
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100169851, 100312956, 100361414
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: B3GLJ2, B3GLJ3
• Gene Symbols: PATE3
• Immunogen: Recombinant full length Human PATE3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG