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Invitrogen™ PAR4 Polyclonal Antibody
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Product Code. 17792244
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Quantity:
100 μL
Unit Size:
100µL
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17792244 100 μL 100µL
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Product Code. 17792244 Supplier Invitrogen™ Supplier No. PA5120851

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Description

Rabbit Polyclonal Antibody

Positive test controls include: BT-474, HT-29, SKOV3, SW480, HepG2. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: QNEAVNLLDP GSSYLLQEPP RTVSGRYKST TSVSEEDVSS RYSRTDRSGF PRYNRDANVS GTLVSSSTLE KKIEDLEKEV VRERQENLRL VRLMQDKEEM I.

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PAR4
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Pawr
Gene Accession No. Q62627, Q925B0, Q96IZ0
Gene Alias 2310001G03Rik; coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2R like thrombin/trypsin receptor 3; F2RL3; PAR4; Par-4; par-4 induced by effectors of apoptosis; Pawr; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; pro-apoptotic WT1 regulator; prostate apoptosis response 4; prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; protease-activated receptor-4; proteinase-activated receptor 4; Thrombin receptor-like 3; transcriptional repressor PAR4; transcriptional repressor Par-4-like protein PAWR; WT1-interacting protein
Gene Symbols Pawr
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAR4 (NP_002574.2).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114774, 5074, 64513
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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