Invitrogen™ PAPPA2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA553798

Product Code. 15771731

Description

Immunogen sequence: GDSSEDGHYF RGHLGTLVFW STALPQSHFQ HSSQHSSGEE EATDLVLTAS FEPVNTEWVP FRDEKYPRLE VLQGFE Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 64%.

PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP)-5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.

Specifications

• Antigen: PAPPA2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAPPA2
• Gene Alias: LOC680415; PAPPA2; PAPP-A2; pappalysin 2; pappalysin-2; Pappe; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1; pregnancy-associated plasma protein-E; RP4-774I24.1; similar to pappalysin 2 isoform 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 60676
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.10 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BXP8
• Gene Symbols: PAPPA2
• Immunogen: Recombinant protein corresponding to Human PAPPA2. Recombinant protein control fragment (Product #RP-91868).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG