Invitrogen™ Pan Dux Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5119724

Product Code. 17771124

Description

Positive Control: Non-transfected 293T cells lysate, His-tagged Dux transfected 293T cells lysate. Subcellular Location: Nucleus.

The double homeobox (DUX) proteins are encoded by 3.3-kilobase repeats found throughout the human genome. The DUX family includes DUX1, DUX2, DUX3, DUX4 and DUX5. Each of these family members, excluding DUX2, contains two homeobox domains. DUX2 contains only one homeobox domain. DUX1 and DUX5 are identical to one another and they share 98% identity with DUX3 and approximately 70% identity with DUX2. The genes encoding DUX5 and DUX3 both contain additional start sites that result in N-terminal extended isoforms. The homeodomains found in DUX5 and DUX1 are similar to those found in Pax-3, Pax-7, OTX1 and OTX2. DUX4, also known as DUX10, is capable of forming homodimers. In addition, the gene encoding DUX4 maps within the D4Z4 repeat unit that has been implicated in Facioscapulohumeral muscular dystrophy (FSHD).

Specifications

• Antigen: Pan Dux
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene Alias: Double homeobox; Dux
• Immunogen: Synthetic peptide within mouse Dux aa 520-570.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 50% glycerol, 0.2% BSA and 0.05% sodium azide; pH 7.4
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG