R&D Systems™ Pan Caspase OPH Inhibitor Q-VD, Non-omethylated

Cell-permeable, irreversible inhibitor of caspase activity. Q-VD-OPh does not exhibit toxic effects at typical working concentrations.

Brand:  R&D Systems™ OPH001-01M

Product Code. 18108090

Description

Members of the caspase gene family (cysteine proteases with aspartate specificity) play significant roles in both inflammation and apoptosis.

• The IC50 range for caspases -1, -3, -8, -9, -10, and -12 is 25 - 400 nM
• Cells that are induced to undergo apoptosis can be cultured in the presence or absence of Q-VD-OPh inhibitor
• The Caspase Inhibitor binds to the active site of activated proteases
• Treated cells can then be assayed for evidence of apoptosis inhibition by examining either whole cells or cell lysates using standard apoptosis assays
• More effective in preventing apoptosis than the widely used pan Caspase Inhibitor, ZVAD-fmk

Specifications

• Product Type: Inhibitor
• Formula Weight: 513.77 d
• Content And Storage: Store the unopened product at -20°C to -70°C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Quantity: 1 mg