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Invitrogen™ PALB2 Polyclonal Antibody

Product Code. 12808952
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12808952 100 μg 100µg
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Product Code. 12808952 Supplier Invitrogen™ Supplier No. PA520796

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Description

Rabbit Polyclonal Antibody

A suggested positive control is SK-N-SH cell lysate. PA5-20796 can be used with blocking peptide PEP-0910.

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen PALB2
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Palb2
Gene Accession No. Q3U0P1, Q86YC2
Gene Alias BC066140; FANCN; FLJ21816; PALB2; Partner and localizer of BRCA2; PNCA3; RGD1304759
Gene Symbols Palb2
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the carboxy terminus of human PALB2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 233826, 293452, 79728
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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