Invitrogen™ PAG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5115714

Product Code. 17268493

Description

Antibody detects endogenous levels of total PAG.

PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and thereby activates the protein tyrosine kinase Csk, the major negative regulator of the Src family kinases. Signaling via the B-cell receptor in B cells or high affinity IgE receptor (FcepsilonRI) in mast cells leads to PAG increased tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding and increased activation of the protein tyrosine kinase Lck.

Specifications

• Antigen: PAG1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PAG1
• Gene Alias: CBP; Csk binding protein; csk-binding protein; F730007C19Rik; Pag; PAG 1; Pag1; PAG1B; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; phosphoprotein membrane anchor with glycosphingolipid microdomains 1; phosphoprotein transmembrane adaptor 1; phosphoprotein-associated with GEMs; pregnancy-associated glycoprotein 1; Pregnancy-specific protein B; PSP-B; similar to pregnancy-associated glycoprotein 1; transmembrane adapter protein PAG; transmembrane adaptor protein PAG; transmembrane phosphoprotein Cbp
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55824, 64019, 94212
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: Q3U1F9, Q9JM80, Q9NWQ8
• Gene Symbols: PAG1
• Immunogen: A synthesized peptide derived from human PAG1(Accession Q9NWQ8), corresponding to amino acid residues V108-G158.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG