Invitrogen™ PADI2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5106273

Product Code. 16612715

Description

Antibody detects endogenous levels of total PADI2.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

Specifications

• Antigen: PADI2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PADI2
• Gene Alias: KIAA0994; mKIAA0994; PAD type II; Pad2; PAD-H19; PADI2; Pdi; PDI2; peptidyl arginine deiminase 2; peptidyl arginine deiminase, type 2; peptidyl arginine deiminase, type II; peptidyl arginine deiminase, type II; PAD type II; peptidylarginine deiminase II; Protein-arginine deiminase type II; protein-arginine deiminase type-2; RP1-37C10.6
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11240, 18600, 29511
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P20717, Q08642, Q9Y2J8
• Gene Symbols: PADI2
• Immunogen: A synthesized peptide derived from human PADI2(Accession Q9Y2J8), corresponding to amino acid residues S495-Q545.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG