Invitrogen™ PABPN1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5102924

Code produit. 16689374

Description

Antibody detects endogenous levels of total PABP2.

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3' ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt. At steady-state, this protein is localized in the nucleus whereas a different poly(A) binding protein is localized in the cytoplasm. This gene contains a GCG trinucleotide repeat at the 5' end of the coding region, and expansion of this repeat from the normal 6 copies to 8-13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD) disease. Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

Spécification

• Antigen: PABPN1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PABPN1
• Gene Alias: mPABII; Nuclear poly(A)-binding protein 1; OPMD; PAB2; PABII; PABP2; PABP-2; Pabp3; PABPN1; poly(A) binding protein 2; poly(A) binding protein II; poly(A) binding protein nuclear 1; poly(A) binding protein, nuclear 1; poly(A)-binding protein 2; poly(A)-binding protein II; polyA binding protein II; polyadenylate-binding nuclear protein 1; Polyadenylate-binding protein 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54196, 8106
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q86U42, Q8CCS6
• Gene Symbols: PABPN1
• Immunogen: A synthesized peptide derived from human PABPN1(Accession Q86U42), corresponding to amino acid residues P252-W302.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG