p63 (deltaN) Rabbit, anti-Human, Unconjugated, Clone: Poly6190, STEMCELL Technologies

Rabbit Monoclonal Antibody

Brand:  Stemcell Technologies 60154

Product Code. 17169191

Description

• The Poly6190 antibody reacts with the deltaN isoforms of human p63, a member of the p53 family of transcription factors
• Alternative splicing of the p63 transcript gives rise to two classes of isoforms
• The TA isoforms (TA p63-α, -β, -γ) possess an N-terminal transactivation domain, while the deltaN isoforms (deltaN p63-α, -β, -γ) lack the transactivation domain
• The TA isoforms are capable of transactivating p53 targets, whereas they antagonize p53
• The deltaN isoforms are generally dominant to the TA isoforms and repress the latter
• The p63 protein is localized to the nucleus and plays an important role in epithelial stem cell regeneration, epidermal morphogenesis, limb development, and stratification

Specifications

• Antigen: p63 (deltaN)
• Classification: Monoclonal
• Conjugate: Unconjugated
• Quantity: 200 μL
• Target Species: Human
• Cell Type: Airway Cells, Dermal Cells

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry, Immunofluorescence
• Clone: Poly6190
• Host Species: Rabbit
• Primary or Secondary: Primary
• Isotype: IgG