p57 ^Kip2 Ab-3, Mouse Monoclonal Antibody,Lab Vision™ Epredia™

Deliver accurate, reproducible results with the Epredia™ p57^Kip2 Ab-3, Mouse Monoclonal Antibody.

Brand:  Epredia MS-897-B1

Product Code. 12622557

Description

p57^Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. The gene encoding human p57^Kip2 is located on chromosome 11p15.5, a region implicated in both sporadic cancers, Wilm's tumor, and Beckwith-Wiedemann syndrome (BWS), a cancer syndrome, making it a tumor suppressor candidate. BWS is characterized by numerous growth abnormalities and an increased risk of childhood tumors. Several types of childhood tumors including Wilms' tumor, adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles, suggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms.

Host Species: Mouse

Clone: KP39

Isotype: IgG2b/κ

Species Reactivity: Human and Mouse. Others not known.

Epitope: Not determined

Immunogen: Recombinant human p57^Kip2 protein

Molecular Weight: 57kDa

Positive Control: LS174T cells, Colon CA or placenta

Cellular Localization: Nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting (Not suitable)
• Immunoprecipitation (Native verified)

Specifications

• Antigen: p57superscriptKip2superscript
• Classification: Monoclonal
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 500 μL
• Research Discipline: Cell Cycle
• Target Species: Human, Mouse
• Isotype: IgG2b κ

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation
• Clone: KP39
• Conjugate: Biotin
• Immunogen: Recombinant human p57superscriptKip2superscript protein
• Regulatory Status: IVD
• Primary or Secondary: Primary
• Form: Concentrated