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  6. Invitrogen™ p53R2 Recombinant Mouse Monoclonal Antibody (K1H015_6B3)

Invitrogen™ p53R2 Recombinant Mouse Monoclonal Antibody (K1H015_6B3)

Product Code. 30829338
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30829338 100 μL
30826644 50 μL
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Product Code. 30829338 Supplier Invitrogen™ Supplier No. MA564463

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Description

Mouse Recombinant Monoclonal Antibody

Immunogen sequence: GLDQDERSSS DTNESEIKSN EEPLLRKSSR RFVIFPIQYP DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK KREFLFNAIE TMPYVKKKAD WALRWIADRK Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 81%, Pig - 93%, Cynomolgus monkey - 98%.

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and -gamma-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumor suppression.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p53R2
Applications Immunohistochemistry (Paraffin)
Classification Recombinant Monoclonal
Clone K1H015_6B3
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.09% sodium azide
Gene Rrm2b
Gene Accession No. Q7LG56
Gene Alias MTDPS8A; MTDPS8B; p53-inducible ribonucleotide reductase small subunit 2 homolog; p53-inducible ribonucleotide reductase small subunit 2 short form beta; p53-inducible ribonucleotide reductase small subunit 2-like protein; p53R2; Ribonucleoside-diphosphate reductase subunit M2 B; ribonucleotide reductase M2 B (TP53 inducible); ribonucleotide reductase regulatory TP53 inducible subunit M2B; RRM2B; TP53-inducible ribonucleotide reductase M2 B
Gene Symbols Rrm2b
Host Species Mouse
Immunogen Recombinant human RRM2B (aa 11-180).
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 50484
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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