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Invitrogen™ p53AIP1 Polyclonal Antibody

Product Code. 12818542
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Quantity:
100 μg
Unit Size:
100µg
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Product Code. Quantity unitSize
12818542 100 μg 100µg
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Product Code. 12818542 Supplier Invitrogen™ Supplier No. PA520355

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Description

Rabbit Polyclonal Antibody

A suggested positive control is HL60 cell lysate. PA5-20355 can be used with blocking peptide PEP-0475.

The novel protein p53AIP, p53-regulated apoptosis-inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser46 regulates the transcriptional activation of this apoptosis inducing gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p53AIP1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene TP53AIP1
Gene Accession No. Q9HCN2
Gene Alias p53AIP1; p53-regulated apoptosis-inducing protein 1; TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
Gene Symbols TP53AIP1
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the amino terminus of human p53AIP1.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 63970
Target Species Human
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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