Invitrogen™ p53 (R175H Mutant) Recombinant Rabbit Monoclonal Antibody (HL1129)

Rabbit Recombinant Monoclonal Antibody

Brand:  Invitrogen™ MA546935

Product Code. 17879475

Description

Store as concentrated solution. Centrifuge briefly prior to opening vial.

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277).

Specifications

• Antigen: p53 (R175H Mutant)
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Alias: BCC7; BMFS5; LFS1; P53; TRP53; tumor protein p53
• Immunogen: Carrier-protein conjugated synthetic peptide surrounding mutant R175H of human p53. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Clone: HL1129
• Conjugate: Unconjugated
• Gene Accession No.: P29466, P48729, Q8N752
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 122011, 1452, 834
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid