Eurofins DiscoverX p53 (expressed in E.coli) Protein

Product Code. 17340844

Brand: Eurofins DiscoverX 14952

Description

N-terminal cMyc and GST-tagged, recombinant, human p53 full length, for use in Kinase Assays

p53 is a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants.

GenBank BC003596.1

Specifications

• Formulation: mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
• Molecular Weight (g/mol): 72 kDa
• Quantity: 10 μg
• Species: Human
• Recombinant: Recombinant
• Protein Tag: N-terminal cMyc and N-terminal GST
• Expression System: Recombinant enzyme expressed in E. coli cells
• Protein Form: Full-length
• Purity or Quality Grade: ≥58%
• Protein: p53