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p53 Antibody (TRP/816), DyLight 680, Novus Biologicals™

Product Code. 18252711 Shop All Bio Techne Products
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Quantity:
100 μL
Unit Size:
100µL
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18252711 100 μL 100µL
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Product Code. 18252711 Supplier Novus Biologicals Supplier No. NBP259628FR

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Description

Mouse Monoclonal Antibody

p53 Monoclonal specifically detects p53 in Human samples. It is validated for Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p53
Applications Western Blot, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunoassay, Immunofluorescence
Classification Monoclonal
Clone TRP/816
Conjugate DyLight 680
Dilution Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockout Validated
Formulation 50mM Sodium Borate with 0.05% Sodium Azide
Gene Alias Antigen NY-CO-13, FLJ92943, LFS1TRP53, p53, p53 tumor suppressor, P53cellular tumor antigen p53, Phosphoprotein p53, transformation-related protein 53, tumor protein p53, Tumor suppressor p53
Gene Symbols TP53
Host Species Mouse
Immunogen Recombinant human full-length p53 protein (Uniprot: P04637)
Purification Method Protein A or G purified
Quantity 100 μL
Regulatory Status RUO
Research Discipline Apoptosis, Cancer, Cell Cycle and Replication, Cellular Markers, Checkpoint signaling, Core ESC Like Genes, DNA Double Strand Break Repair, DNA Repair, HIF Target Genes, Hypoxia, Neuroscience, Neurotransmission, p53 Pathway, Phospho Specific, Stem Cell Markers, Transcription Factors and Regulators, Tumor Suppressors
Primary or Secondary Primary
Gene ID (Entrez) 7157
Test Specificity The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Target Species Human
Content And Storage Store at 4C in the dark.
Form Purified
Isotype IgG2a κ
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For Research Use Only (RUO)

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