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Invitrogen™ p27 Kip1 Recombinant Rabbit Monoclonal Antibody (5H10L14)

Product Code. 16535631
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Quantity:
100 μg
Unit Size:
100µg
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16535631 100 μg 100µg
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Product Code. 16535631 Supplier Invitrogen™ Supplier No. 703608

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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Mouse, Rat, Bovine.

p27 Kip1 functions as a negative regulator of G1 mouse expression and has been proposed to function as a possible mediator of TGFb induced G1 arrest. p27 Kip1 is an important regulator of cell cycle progression, a potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. p27 Kip1 forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. p27 Kip1 acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. p27 Kip1 has a molecular weight of approximately 27kDa and the degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p27 Kip1
Applications Western Blot, Immunocytochemistry, Western Blot
Classification Recombinant Monoclonal
Clone 5H10L14
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene Cdkn1b
Gene Accession No. P46527
Gene Alias AA408329; AI843786; Cdki1b; CDKN1B; CDKN4; CDN1B; cyclin dependent kinase inhibitor 1B; cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (p27 Kip1); Cyclin-dependent kinase inhibitor 1B (p27, Kip1); cyclin-dependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor p27 Kip1; cyclin-dependent kinase inhibitor p27/Kip1; KIP1; MEN1B; MEN4; p27; P27 CDKN1B; p27(KIP1); p27Kip1
Gene Symbols Cdkn1b
Host Species Rabbit
Immunogen Protein corresponding to human p27Kip1 [aa1-aa198].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1027
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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