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  6. Invitrogen™ p23 Recombinant Rabbit Monoclonal Antibody (K01_2N74)

Invitrogen™ p23 Recombinant Rabbit Monoclonal Antibody (K01_2N74)

Product Code. 30829623
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30829623 50 μL
30827837 100 μL
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Product Code. 30829623 Supplier Invitrogen™ Supplier No. MA565616
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Estimated Shipment: 11-09-2026
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Description

Rabbit Recombinant Monoclonal Antibody

p23 Recombinant Monoclonal Antibody for ICC/IF, Western Blot

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. Prior to activation, steroid receptors associate with a number of different proteins in both a stable and transient fashion. Steroid receptor complex proteins include heat shock proteins (HSP70 and HSP90), immunosuppressant binding proteins called immunophilins (the FK506 binding proteins, FKBP52 & FKBP54 and the cyclosporin binding protein, CyP-40) and at least three other proteins termed p23, p60 and p48. p23 along with HSP70, HSP90 and p60, combine with progesterone receptor (PR) as members of a transient intermediate complex. Cloned human p23 encodes a protein of 160 amino acids that is highly conserved between species and shows no homology to previously identified proteins. p23 is a highly acidic phosphoprotein with an aspartic acid-rich C-terminal domain and multiple potential phosphorylation sites. In vitro studies have suggested that p23 binds to HSP90 and is necessary for the binding of HSP90 and CyP-40 to PR. While neither its exact function nor mechanism of action have been identified, p23 appears to be an important factor in PR function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen p23
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone K01_2N74
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 50mM tris glycine with 0.05% BSA, 40% glycerol, 150mM NaCl and 0.01% sodium azide; pH 7.4
Gene Ptges3
Gene Accession No. P83868, Q15185, Q9R0Q7
Gene Alias 5730442A20Rik; Co chaperone p23; cPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co chaperone; Hsp90 co-chaperone; LOC100351480; P23; p23 cochaperone; progesterone receptor; progesterone receptor complex p23; Prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic); prostaglandin-E synthase 3; Ptges; PTGES3; ptges3 {ECO:0000250; RGD1561913; sid 3177; Sid3177; Tebp; telomerase binding protein, p23; telomerase-binding protein p23; unactive progesterone receptor, 23 kD; UniProtKB:Q15185}
Gene Symbols Ptges3
Host Species Rabbit
Immunogen A synthetic peptide of human p23/PTGES3.
Purification Method Protein A/G
Quantity 50 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10728, 362809, 56351
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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