Invitrogen™ TK2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA513813

Product Code. 10546290

Description

TK2 Polyclonal Antibody for Western Blot

Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.

Specifications

• Antigen: TK2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Tk2
• Gene Alias: AU024611; MTDPS2; MTTK; Mt-TK; SCA31; thymidine kinase 2, mitochondrial; thymidine kinase 2; thymidine kinase 2, mitochondrial; TK2
• Host Species: Rabbit
• Purification Method: Ammonium Sulfate Precipitation, Size-exclusion - Dialysis
• Regulatory Status: RUO
• Gene ID (Entrez): 57813, 7084
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1.6 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O00142, Q9R088
• Gene Symbols: Tk2
• Immunogen: KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG