Invitrogen™ OXPAT Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5117687

Product Code. 17260184

Description

This antibody has been tested in direct-ELISA.

Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE.

Specifications

• Antigen: OXPAT
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Plin5
• Gene Alias: 2310076L09Rik; AI415325; AW109675; lipid droplet associated protein; lipid droplet-associated protein PAT-1; Lipid storage droplet protein 5; LSDA5; LSDP5; Mldp; Myocardial LD protein; Oxpat; Pat1; PAT-1; perilipin 5; perilipin-5; Plin5
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 440503, 66968
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 3 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300, 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q00G26, Q8BVZ1
• Gene Symbols: Plin5
• Immunogen: Recombinant Human Perilipin-5 protein (305-453aa).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG