ORMDL1 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA521146

Product Code. 12829292

Description

A suggested positive control is SK-N-SH cell lysate. PA5-21146 can be used with blocking peptide PEP-1260.

The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3 that may play roles in -gamma-secretase complex maturation. Localized to the membrane of the endoplasmic reticulum, ORMDLs are widely expressed and are implicated in the expression of Presenilin (PSI) which is involved in Alzheimer's disease (AD). Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDLs have recently been identified as a potential risk factor for childhood asthma.

Specifications

• Antigen: ORMDL1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ORMDL1
• Gene Alias: Adoplin-1; C730042F17Rik; HSPC202; ORM1-like 1; ORM1-like 1 (S. cerevisiae); ORM1-like protein 1; ORMDL sphingolipid biosynthesis regulator 1; ORMDL1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100188936, 227102, 94101
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q921I0, Q9P0S3
• Gene Symbols: ORMDL1
• Immunogen: A 16 amino acid peptide of human ORMDL1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG