Invitrogen™ ORM2 Monoclonal Antibody (D1), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen™ MA543636

Product Code. 17604096

Description

AGP (a 1-acid Glycoprotein) is an acute phase plasma protein synthesized by the liver. It functions to regulate the interaction between blood cells and endothelial cells, and together with haptoglobin and C reactive protein, it also mediates the extravasation of cells during infection and inflammation. Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. AGP has a high affinity, low capacity binding for basic drugs at physiological pH. In human plasma, AGP is found at levels of 0.5-1.4 mg/mL, though this is elevated during acute inflammation, and, as a result, levels of this protein can be used to diagnose inflammatory conditions. Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3 and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively. Abnormal expression of the APG-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the APG-2 gene are associated with different types of carcinomas.

Specifications

• Antigen: ORM2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P19652
• Gene Symbols: ORM2
• Immunogen: Gln19-Ser201 (Accession P19652), with N-terminal His Tag.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: D7
• Conjugate: Unconjugated
• Gene: ORM2
• Gene Alias: AGP 2; Agp1; AGP2; Agp-2; AGP-B; AGP-B'; alpha-1-acid glycoprotein 1; alpha-1-acid glycoprotein 2; alpha-1-acid glycoprotein, type 2; bM340H1.5 (orosomucoid 2); OMD 2; OMD2; ORM2; Orm-2; orosomucoid 2; Orosomucoid2; orosomucoid-2
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 5005
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid