Invitrogen™ Optineurin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA580873

Product Code. 16397944

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human Optineurin/OPTN.

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14. 7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Specifications

• Antigen: Optineurin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: OPTN
• Gene Alias: 14.7K-interacting protein 2; 4930441O07Rik; Ag9 C5; ALS12; E3-14.7K-interacting protein; FIP 2; FIP2; FIP-2; FIP-2-like protein; GLC1E; HIP 7; HIP7; HIP-7; Huntingtin interacting protein L; huntingtin yeast partner L; Huntingtin-interacting protein 7; huntingtin-interacting protein L; HYPL; NEMO-related protein; NRP; Optic neuropathy-inducing protein; optineurin; Optn; TFIIIA IntP; TFIIIA-IntP; transcription factor IIIA-interacting protein; transcrption factor IIIA-interacting protein; tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains; Uban
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 10133
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: ELISA, Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q96CV9
• Gene Symbols: OPTN
• Immunogen: Recombinant Human Optineurin/OPTN Protein (Met1-Ile577).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG