Invitrogen™ Reelin Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5149714

Product Code. 31034516

Description

Immunogen sequence: QYSNDNGILW HLLRELDFMS FLEPQIISID LPQDAKTPAT AFRWWQPQHG KHSAQWALDD VLIGMNDSSQ TGFQDKFDGS IDLQANWYRI QGGQVDIDCL Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.

Reelin in an extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation.

Specifications

• Antigen: Reelin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RELN
• Gene Alias: ETL7; extracellular matrix serine protease; LIS2; PRO1598; Reelen; reeler; Reeler protein; Reelin; RELN; Rl
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5649
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P78509
• Gene Symbols: RELN
• Immunogen: Recombinant protein corresponding to Human RELN.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG