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Description
Immunogen sequence: NPAGIPHFVH RELKSEKVEQ IKLAMNQQCD VSQEALDIQR LPFYPDMVNR DTKMASNPRK CMAASLDVHE ENIPTVMSAG EMDKWKGIEP GEKCADRSPV CTTFSDTSSN INSILELFPK LLCLDGQQSP RATLCGTEAH KRL Highest antigen sequence identity to the following orthologs: Mouse - 45%, Rat - 41%.
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.
Specifications
Specifications
| Antigen | NXF3 |
| Applications | Immunohistochemistry (Paraffin) |
| Classification | Polyclonal |
| Concentration | 0.1 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | NXF3 |
| Gene Accession No. | Q9H4D5 |
| Gene Alias | Nuclear RNA export factor 3; NXF3; RGD1564923; TAPL3; TAPL-3; TAP-like protein 3 |
| Gene Symbols | NXF3 |
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