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Tocris Bioscience™ NX 1607

Product Code. 31794365
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Product Code. 31794365 Supplier Tocris Bioscience™ Supplier No. 8950/10
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Estimated Shipment: 30-09-2026
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133.39 GBP valid until 2026-09-30
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This item is not returnable. View return policy
To receive the discount customers must purchase three of the same product at list price in a single order to receive 33.33% discount. There is no limit to the multiples of 3 that customers can buy. Use promo code ”27950” to get your promotional price

Description

CBL-B intramolecular glue inhibitor

NX 1607 (Cbl-b-IN-3) is an inhibitor of CBL-B (Casitas B-lineage lymphoma proto-oncogene B), a RING-type E3 ubiquitin ligase. NX 1607 acts as an intramolecular glue. In vitro, NX 1607 activates MAPK/ERK signaling pathway and enhances T-cell activation in primary T cells and Jurkat T cells. In vivo, NX 1607 decreases tumor growth in cell lymphoma models. NX 1607 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2,3-Dihydro-2-[3-[cis-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-6-[[(3S)-3-methyl-1-piperidinyl]methyl]-4-(trifluoromethyl)-1H-isoindol-1-one
CAS 2573775-59-2
Quantity 10 mg
Target Molecular Glues
Molecular Formula C30H34F3N5O
Purity 98%
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