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NVP-2, MedChemExpress

Product Code. p-200098510
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Product Code. 16491257 Supplier Medchem Express Supplier No. HY12214A

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Description

MedChemExpress NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces cell apoptosis.

NVP-2 is a potent and selective ATP-competitive cyclin dependent kinase 9 (CDK9) probe, inhibits CDK9/CycT activity with an IC50 of 0.514 nM. NVP-2 displays inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases with IC50 values of 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces cell apoptosis.

Specifications

Chemical Name or Material NVP-2
CAS 1263373-43-8
Color Off-White
Purity Grade Notes Research
Molecular Formula C27H37ClN6O2
Quantity 50 mg
Solubility Information DMSO : ≥ 100 mg/mL (194.91 mM)
SMILES ClC1=CN=C(N[C@H]2CC[C@H](N[C@H](C)COC)CC2)C=C1C3=CC=CC(NCC4(C#N)CCOCC4)=N3
Molecular Weight (g/mol) 513.07
Formula Weight 513.07
Percent Purity 98.0%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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