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Tocris Bioscience™ NVP 2

Product Code. 18749066
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5 mg
Unit Size:
5mg
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Product Code. 18749066 Supplier Tocris Bioscience™ Supplier No. 6535/5

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211.60 GBP valid until 2026-03-31
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Description

Potent and selective ATP-competitive CDK9 inhibitor

NVP 2 is a potent and selective ATP-competitive CDK9 inhibitor (IC50 = 0.5 nM). Exhibits selectivity for CDK9 over a panel of 468 kinases, but inhibits DYRK1B (IC50 = 350 nM), displays <90% binding to CDK7 (IC50 >10 μM) and CDK13. Inhibits proliferation of MOLT4 cells in vitro. Induces apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 4-[[[5'-Chloro-2'-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4'-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile
CAS 1263373-43-8
Quantity 5 mg
Molecular Formula C27H37ClN6O2
Formula Weight 513.07
Product Type Inhibitor
Purity 97%
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