Invitrogen™ NUP88 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Product Code	Brand	Quantity
17999572	Invitrogen™ PA5145282	20 μL
17948772	Invitrogen™ PA5145281	200 μL

Description

The nuclear pore complex (NPC) mediates bidirectional macromolecular traffic between the nucleus and cytoplasm in eukaryotic cells and is comprised of more than 100 different subunits. Many of the subunits belong to a family called nucleoporins (Nups), which are characterized by the presence of O-linked-N-acetylglucosamine moieties and a distinctive pentapeptide repeat (XFXFG). Nup88 (nucleoporin 88 kDa) is a 741 amino acid protein that localizes to the nucleus and functions as an essential component of the nuclear pore complex. Expressed ubiquitously, Nup88 is subject to phosphorylation by ATM or ATR and is upregulated in malignant neoplasms and precancerous dysplasias, suggesting a role in tumorigenesis. The gene encoding Nup88 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1, 200 genes.

Specifications

• Antigen: NUP88
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q8CEC0, Q99567
• Gene ID (Entrez): 19069, 4927
• Immunogen: Recombinant Mouse NUP88 protein, Leu57-Gly296 (Accession #Q5QNU0).
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

• Concentration: 0.5 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.05% Proclin 300; pH 7.4
• Gene Alias: 88 kDa nuclear pore complex protein; 88 kDa nucleoporin; karyoporin; nuclear pore complex protein 88; nuclear pore complex protein Nup88; nucleoporin 88; nucleoporin 88kDa; nucleoporin Nup84; Nucleoporin Nup88; Nup84; NUP88; Prei2; preimplantation protein 2
• Gene Symbols: NUP88
• Isotype: IgG
• Purification Method: Antigen affinity chromatography, Protein A
• Gene: NUP88