NUP107 Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA520563

Product Code. 12828742

Description

A suggested positive control is A549 cell lysate. PA5-20563 can be used with blocking peptide PEP-0683.

The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.

Specifications

• Antigen: NUP107
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NUP107
• Gene Alias: 107 kDa nucleoporin; AW541137; BcDNA.LD18761; BcDNA:LD18761; C76801; CG6743; CG6743-PA; Dmel\CG6743; Dmel_CG6743; dmNup107; NPHS11; nuclear pore complex; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup107-like protein; nucleoporin 107; Nucleoporin 107kD; nucleoporin 107kDa; nucleoporin Nup107; Nup; Nup 107; nup107; Nup107-PA; Nup170; NUP84; p105
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116555, 57122
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunocytochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P52590, P57740
• Gene Symbols: NUP107
• Immunogen: A 15 amino acid peptide from near the carboxy terminus of human NUP107.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG