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NUMB Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA116831
Code : LD
Additional Details : Weight : 0.01000kg
Description
The target sequence has 90% sequence homology with rat.
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.Specifications
NUMB | |
Polyclonal | |
Unconjugated | |
Numb | |
c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
18222, 395639, 8650 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Immunocytochemistry, Western Blot | |
3.5 mg/mL | |
tris glycine with 0.15M NaCl and 0.05% sodium azide | |
P49757, Q9QZS3 | |
Numb | |
A synthetic peptide made to a C-terminal region of the murine numb protein sequence (between residues 600-653). | |
100 μL | |
Primary | |
Chicken, Human, Mouse | |
Antibody | |
IgG |