Invitrogen™ NUMB Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5119316

Product Code. 17720724

Description

NUMB Polyclonal Antibody for Western Blot, ICC/IF, IHC (P)

Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.

Specifications

• Antigen: NUMB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Numb
• Gene Alias: c14_5527; C14orf41; h-Numb; mnb; m-Nb; m-numb; Nb; NUMB; NUMB endocytic adaptor protein; numb gene homolog; numb gene homolog (Drosophila); numb homolog; numb homolog (Drosophila); NUMB isoform 3; Numb variant 1; Numb variant 2; NUMB, endocytic adaptor protein; protein numb homolog; Protein S171; PTB domain protein; S171
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 18222, 8650
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.5 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.4
• Gene Accession No.: P49757, Q9QZS3
• Gene Symbols: Numb
• Immunogen: Recombinant protein Numb Homolog. The antigen corresponds to amino acid range 376-482 of the target protein.
• Quantity: 200 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG