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STEMCELL Technologies NU7026

Product Code. 17120342
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25 mg
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17120342 5 mg 5mg
17130342 25 mg 25mg
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Product Code. 17120342 Supplier STEMCELL Technologies Supplier No. 74172

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Description

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

  • NU7026 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway
  • NU7026 sensitizes cells to radiation and has potential for anticancer therapies (Veuger et al.) NU7026 is also reported to increase the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Riesenberg & Maricic; Zhang et al.)
  • Increases precise genome editing by promoting HDR at the expense of NHEJ in human pluripotent stem cells (Riesenberg & Maricic; Zhang et al.)
  • Sensitizes human cancer cell lines to DNA double-strand break-inducing therapy (chemo- or radio-therapy) by inhibiting DNA-PK activity and inducing cell cycle arrest at G2/M phase (Albarakati et al.; Ma et al.; Niazi et al.; Willmore et al.; Yang et al.)

Specifications

CAS 154447-35-5
Synonym LY293646; DNA-PK Inhibitor II
Quantity 5 mg
Molecular Formula C17H15NO3
Purity ≥95%
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