Invitrogen™ NSMCE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA559625

Product Code. 15727481

Description

Immunogen sequence: RRMGVMTDVH RRFLQLLMTH GVLEEWDVKR LQTHCYKVHD RNATVDKLED FINNINSVLE SLYIEIKRGV TEDDGRPIYA LVN Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.

The NSMCE1 (Non-SMC Element 1 Homolog) gene encodes a protein that is a key component of the SMC5-SMC6 complex, which is essential for DNA repair and the maintenance of genomic stability. Located on chromosome 16, the NSMCE1 protein interacts with other components of the SMC5-SMC6 complex, including SMC5, SMC6, and NSMCE2, facilitating the repair of DNA double-strand breaks and promoting chromosome segregation during cell division. NSMCE1 is particularly involved in homologous recombination, a critical pathway for error-free DNA repair. Mutations or deficiencies in NSMCE1 can lead to genomic instability, increased sensitivity to DNA-damaging agents, and have been associated with several genetic disorders and cancer predispositions.

Specifications

• Antigen: NSMCE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSMCE1
• Gene Alias: 2510027N19Rik; HSPC333; HSPC337; Non-SMC element 1 homolog; non-SMC element 1 homolog (S. cerevisiae); non-structural maintenance of chromosomes element 1 homolog; NSE1; NSE1 homolog, SMC5-SMC6 complex component; Nsmce1; RGD1307760
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 197370
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8WV22
• Gene Symbols: NSMCE1
• Immunogen: Recombinant protein corresponding to Human NSMCE1. Recombinant protein control fragment (Product #RP-98763).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG