Invitrogen™ NSD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA567097

Product Code. 15919774

Description

Immunogen sequence: FSDVHFDSKVK QSDPGKISEK GLSFENGKGP ELDSVMNSEN DELNGVNQVV PKKRWQRLNQ RRTKPRKRMN RFKEKENSEC Highest antigen sequence identity to the following orthologs - mouse 80%, rat 72%.

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Specifications

• Antigen: NSD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NSD1
• Gene Alias: AI528500; Androgen receptor coactivator 267 kDa protein; androgen receptor-associated coregulator 267; androgen receptor-associated protein of 267 kDa; ARA267; H3-K36-HMTase; H4-K20-HMTase; Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific; KMT3B; Lysine N-methyltransferase 3B; NR-binding SET domain-containing protein; NSD1; nuclear receptor binding SET domain protein 1; nuclear receptor-binding SET domain-containing protein 1; nuclear receptor-binding SET-domain protein 1; SOTOS; SOTOS1; STO
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 64324
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96L73
• Gene Symbols: NSD1
• Immunogen: Recombinant Human NSD1. Recombinant protein control fragment (Product #RP-107743).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG