Tocris Bioscience™ NR 7h

Product Code. 18717546

Brand: Tocris Bioscience™ 7177/5

Description

Potent and selective p38α and p38β Degrader (PROTAC™); active in vivo

NR 7h is a potent and selective p38α and p38β Degrader (PROTAC™) (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. NR 7h impairs replication of Mayaro virus in human dermal fibroblasts and HeLa cells. Active in vivo.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Chemical Name or Material: 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2 H)-yl)-N-(4-(1-(4-((4-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)butyl)amino)-4-oxobutyl)-1 H-1,2,3-triazol-4-yl)butyl)-4-methylbenzamide
• CAS: 2550399-06-7
• Quantity: 5 mg
• Target: Active Degraders
• Molecular Formula: C₄₈H₅₀BrF₂N₉O₈
• Formula Weight: 3636
• Purity: 97%