Invitrogen™ NPTX2 Polyclonal Antibody

Product Code.	Quantity	unitSize
12818702	100 μg	100µg

Product Code. 12818702 Supplier Invitrogen™ Supplier No. PA520521

Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-20521 can be used with blocking peptide PEP-0641.

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.

Specifications

• Antigen: NPTX2
• Applications: Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.02% sodium azide
• Gene: NPTX2
• Gene Accession No.: O70340, P47972, P97738
• Gene Alias: apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2
• Gene Symbols: NPTX2
• Host Species: Rabbit
• Immunogen: A 16 amino acid peptide near the center of the human NPTX2.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 288475, 4885, 53324
• Target Species: Human, Mouse, Rat
• Content And Storage: 4°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG