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Invitrogen™ NPTX2 Polyclonal Antibody

Product Code. 12818702
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Quantity:
100 μg
Unit Size:
100µg
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12818702 100 μg 100µg
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Product Code. 12818702 Supplier Invitrogen™ Supplier No. PA520521

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Description

Rabbit Polyclonal Antibody

A suggested positive control is mouse brain tissue lysate. PA5-20521 can be used with blocking peptide PEP-0641.

Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NPTX2
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NPTX2
Gene Accession No. O70340, P47972, P97738
Gene Alias apexin; Narp; neuro activity regulated petaxin; neuronal activity-regulated pentaxin; neuronal activity-regulated pentraxin; neuronal pentraxin 2; neuronal pentraxin II; Neuronal pentraxin-2; NP2; NP-II; Nptx2
Gene Symbols NPTX2
Host Species Rabbit
Immunogen A 16 amino acid peptide near the center of the human NPTX2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 288475, 4885, 53324
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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