Invitrogen™ NPR2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA599836

Product Code. 16624085

Description

Antibody detects endogenous levels of total NPR2.

This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Specifications

• Antigen: NPR2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Npr2
• Gene Alias: AMDM; ANPb; ANP-B; ANPRB; ANPR-B; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; atrial natriuretic peptide receptor type B; cn; ECDM; GC-B; GC-B2; GC-B3; guanylate cyclase 2B; guanylate cyclase B; guanylyl cyclase-B; GUC2B; GUCY2B; mNPR-B; natriuretic peptide receptor 2; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; Nppb receptor; NPR2; NPRB; NPR-B; NPRBi; pwe; SNSK
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116564, 230103, 4882
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P16067, P20594, Q6VVW5
• Gene Symbols: Npr2
• Immunogen: A synthesized peptide derived from human NPR2(Accession P20594), corresponding to amino acid residues S647-L697.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG