Invitrogen™ NPL Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA5140278

Product Code. 17894790

Description

Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: FVNGTTGEGL SLSVSERRQV AEEWVTKGKD KLDQVIIHVG ALSLKESQEL AQHAAEIGAD Highest antigen sequence indentity to the following orthologs: Rat - 90%, Mouse - 88%.

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N- glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Specifications

• Antigen: NPL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NPL
• Gene Alias: 0610033B02Rik; C112; C1orf13; dihydrodipicolinate synthetase homolog 1; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate lyase; N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase); N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NAL; NALase; Npl; NPL1; Sialate lyase; sialate-pyruvate lyase; Sialic acid aldolase; sialic acid lyase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80896
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BXD5
• Gene Symbols: NPL
• Immunogen: Recombinant protein corresponding to Human NPL. Recombinant protein control fragment (Product #RP-109500).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG