NPHS2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Brand:  Proteintech 20384-1-AP-20UL

Product Code. 16879914

Description

The pathological conditions of SRN1 correlate well with mutations at the NPHS2 gene, where expression of a protein known as Podocin occurs. Abnormal or inefficient signaling through Podocin protein-dependent networks contributes to the development of podocyte dysfunction and proteinuria. The human NPHS2 gene maps to chromosome 1q25-q31 and encodes a 383 amino acid protein. Podocin is an integral membrane protein that appears to fold into a hairpin-like structure with intracellular amino- and carboxy-termini. Transmembrane and cytoplasmic portions of Podocin share homology to the corresponding regions of the stomatin family proteins. Expression of high-order oligomers of Podocin in glomerular podocytes may reflect a scaffolding function that influences proper function of the glomerular filtration barrier, which is necessary for renal stability.

Specifications

• Antigen: NPHS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NPHS2
• Gene Alias: NPHS2, PDCN, Podocin, SRN1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 170484, 170672, 7827
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Immunohistochemistry (Paraffin), Immunofluorescence, Western Blot, Immunocytochemistry
• Concentration: 0.22 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q8K4G9, Q91X05, Q9NP85
• Gene Symbols: Nphs2
• Immunogen: NPHS2 Fusion Protein Ag14213
• Quantity: 20 μL
• Primary or Secondary: Primary
• Target Species: Rat, Mouse, Human
• Product Type: Antibody
• Isotype: IgG