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Invitrogen™ NPC1 Polyclonal Antibody

Product Code. 12838902
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Quantity:
100 μg
Unit Size:
100µg
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12838902 100 μg 100µg
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Product Code. 12838902 Supplier Invitrogen™ Supplier No. PA520753

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Description

Rabbit Polyclonal Antibody

A suggested positive control is human kidney tissue lysate. PA5-20753 can be used with blocking peptide PEP-0867.

Mutations in the Niemann-Pick disease type C1 (NPC1) gene result in a fatal progressive neurodegenerative disorder characterized by an abnormal sequestration of lipids including cholesterol and glycosphingolipids. The NPC1 protein is a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. NPC1 transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolyzed and released as free cholesterol. NPC1, in addition to FTO, MC4R, and PTER has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NPC1
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NPC1
Gene Accession No. O15118, O35604
Gene Alias A430089E03Rik; C85354; Cdig2; D18Ertd139e; D18Ertd723e; FLJ98532; I79_014078; lcsd; Niemann Pick type C1; Niemann-Pick C disease protein; niemann-Pick C1 protein; Niemann-Pick disease, type C1; Niemann-Pick type C1; Niemann-Pick type C1 protein; nmf164; NPC; NPC intracellular cholesterol transporter 1; NPC1; sphingomyelinosis; spm; truncated Niemann-Pick C1
Gene Symbols NPC1
Host Species Rabbit
Immunogen A 16 amino acid peptide from near the carboxy terminus of human NPC1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18145, 4864
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG
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