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Invitrogen™ NPAS3 Polyclonal Antibody

Product Code. 12828552
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Quantity:
100 μg
Unit Size:
100µg
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12828552 100 μg 100µg
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Product Code. 12828552 Supplier Invitrogen™ Supplier No. PA520365

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Description

Rabbit Polyclonal Antibody

A suggested positive control is rat brain tissue lysate. PA5-20365 can be used with blocking peptide PEP-0485.

Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NPAS3
Applications Immunohistochemistry, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene NPAS3
Gene Accession No. Q8IXF0, Q9QZQ0
Gene Alias 4930423H22Rik; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; member of PAS protein 6; MOP6; neuronal PAS domain protein 3; neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS3; PAS domain-containing protein 6; PASD6
Gene Symbols NPAS3
Host Species Rabbit
Immunogen a 28 amino acid peptide from near the center of human NPAS3.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27386, 299016, 64067
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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