Invitrogen™ NOX3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA538036

Product Code. 15594961

Description

PA5-38036 detects Nox3 in mouse bone marrow and humanG-CSF mobilized CD34+ cells in immunofluorescence analysis. A recommended positive control is 293 cell lysate. NOX3 is not expected to cross-react with other NOX proteins.

The NOX family of NAPDH oxidases is comprised of seven transmembrane proteins that oxidize intracellular NAPDH/NADH, causing electron transport across the membrane and the reduction of molecular oxygen to superoxide. NOX3 is expressed predominantly in the inner ear and is involved in the biogenesis of otoconia/otolith. It has been suggested that NOX3 is activated by the Transient Receptor Potential Vanilloid 1 (TRPV1), and this activity causes increased levels of reactive oxygen species in the inner ear, which in turn leads to STAT1-mediated inflammation and hearing loss.

Specifications

• Antigen: NOX3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOX3
• Gene Alias: GP91-3; gp91phox homolog 3; head-tilt; het; Mitogenic oxidase 2; MOX2; MOX-2; NADPH oxidase 3; NADPH oxidase catalytic subunit-like 3; NAPDH oxidase 3; nmf250; Nox3; NOX-3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 224480, 50508
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q672J9, Q9HBY0
• Gene Symbols: NOX3
• Immunogen: 15 amino acid peptide near the amino terminus of human NOX3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG