Novobiocin Sodium Salt, MP Biomedicals™

Product Code. 17660877

Brand: MP Biomedicals 0215595701

Description

Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II. Novobiocin Sodium Salt, MP Biomedicals is an antibiotic produced by Streptomyces nieveus. It is active against gram-positive bacteria. It is also a Hsp90 inhibitor 3.

Novobiocin inhibits DNA synthesis by inhibiting bacterial DNA gyrase targeting the GyrB subunit of the enzyme involved in energy transduction. It acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB 2. Uses include:

• For the production of positively supercoiled plasmid DNA
• Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase
• Inhibitor of retrovirus RNA-dependent DNA-polymerase
• To study heat shock protein inhibition

Specifications

Chemical Identifiers

• CAS: 1476-53-5
• Molecular Formula: C31H35N2NaO11
• Molecular Weight (g/mol): 634.61
• MDL Number: MFCD00066541,MFCD00066541
• InChI Key: AXOUUAINTJNFRS-UHFFFAOYNA-N
• Synonym: Albamycin, Cathomycin sodium
• PubChem CID: 131673945
• SMILES: [Na+].COC1C(OC(N)=O)C(O)C(OC2=CC=C3C(=O)[C-](NC(=O)C4=CC=C(O)C(CC=C(C)C)=C4)C(=O)OC3=C2C)OC1(C)C

• Physical Form: Powder
• Absorbance: λ max: 307nm
• Melting Point: 220°C
• Extinction Coefficient: E1%= 600 (0.1M NAOH)
• Potency: ∼900μg/mg
• Quantity: 1 g
• Optical Rotation: −38.0° (2.5g/100ml ethanol at 24°C for the free acid)
• Solubility Information: Freely soluble in water (10%, clear, colorless solution)
• IUPAC Name: sodium 7-{[4-(carbamoyloxy)-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy}-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido]-8-methyl-2,4-dioxo-3,4-dihydro-2H-1-benzopyran-3-ide
• Formula Weight: 634.6

Safety and Handling

Product Identifier

• Novobiocin Sodium Salt

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin sensitiser Category 1

Hazard Statement

• H317-May cause an allergic skin reaction.
• H319-Causes serious eye irritation.

Precautionary Statement

• P101-If medical advice is needed, have product container or label at hand.
• P102-Keep out of reach of children.
• P103-Read label before use.
• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P333+P313-If skin irritation or rash occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : Novobiocin Sodium Salt