Invitrogen™ Nova-2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA583784

Product Code. 16380735

Description

Immunogen sequence: GFLTAEKLAA ESAKELVEIA VPE Highest antigen sequence indentity to the following orthologs: Rat - 100%, Mouse - 100%.

Paraneoplastic opsoclonus myoclonus ataxia (POMA) is a neurologic disorder thought to be mediated by an autoimmune attack against onconeural disease antigens that are expressed by gynecologic or lung tumors and by neurons. Nova-1 and -2 are both POMA disease antigens. The autoimmune attack against Nova-2 in POMA patients results in latent cancer, reduced inhibitory control of movements, and dementia. Nova-2 is closely related to Nova-1, and is expressed at high levels in neurons during development and at lower levels in the adult lung. In the postnatal mouse brain, Nova-2 is expressed in a pattern that is largely reciprocal with Nova-1, including high levels of Nova-2 expression in the neocortex and hippocampus. Both Novas are RNA binding proteins, and Nova-2 binds RNA with high affinity and with sequence specificity that differs from Nova-1. They regulate neuronal pre-messenger RNA splicing by directly binding to RNA. Nova-2 target genes function either in the synapse or in axon guidance indicating that Nova-2 is a major regulator of synaptic function.

Specifications

• Antigen: Nova-2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOVA2
• Gene Alias: ANOVA; astrocytic NOVA1-like RNA-binding protein; Gm1424; neuro-oncological ventral antigen 2; neuro-oncological ventral antigen 3; NOVA alternative splicing regulator 2; NOVA2; NOVA3; RNA-binding protein Nova-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4858
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UNW9
• Gene Symbols: NOVA2
• Immunogen: Recombinant protein corresponding to Human NOVA2. Recombinant protein control fragment (Product #RP-100757).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG