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Invitrogen™ NOV Polyclonal Antibody
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Product Code. 13462007
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Quantity:
100 μL
Unit Size:
100µL
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13462007 100 μL 100µL
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Product Code. 13462007 Supplier Invitrogen™ Supplier No. PA527893

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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, mouse brain, human CCN3-transfected 293T cells. Predicted reactivity: Mouse (84%), Rat (83%), Rhesus Monkey (100%), Bovine (82%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

NOV is a member of the CCN family of secreted, cysteine-rich regulatory proteins. The full-length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm's tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorigenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell-surface integrins, and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities.
TRUSTED_SUSTAINABILITY

Specifications

Antigen NOV
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.92 mg/mL
Conjugate Unconjugated
Formulation PBS with 20% glycerol and 0.025% ProClin 300; pH 7
Gene CCN3
Gene Accession No. P48745
Gene Alias C130088N23Rik; CCN family member 3; CCN3; Cellular communication network factor 3; IBP-9; IGF-binding protein 9; IGFBP9; IGFBP-9; Insulin-like growth factor-binding protein 9; Nephro blastoma-overexpressed gene protein homolog; nephroblastoma overexpressed; nephroblastoma overexpressed gene; nephroblastoma overexpressed gene protein homolog; nephroblastoma-overexpressed gene protein homolog; NOV; NovH; protein NOV homolog
Gene Symbols CCN3
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human CCN3. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4856
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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