Learn More
NOTCH1 Monoclonal Antibody (22E5), APC, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£204.00
Specifications
Clone | 22E5 |
---|---|
Concentration | 0.2 mg/mL |
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | APC |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15320750
|
Affymetrix eBioscience
17-5765-82 |
100 μg |
£204.00
100µg |
Estimated Shipment: 03-06-2024 Log in to see stock. |
Please sign in to purchase this item. Need a web account? Register with us today! | ||||
Description
Description: This 22E5 monoclonal antibody reacts with the extracellular domain of mouse Notch1, one of four members of the Notch family of receptors. Notch receptors are 300-kDa single-pass transmembrane proteins. While the extracellular domain contains numerous epidermal growth factor-like repeats for ligand binding, the intracellular domain is involved in cell signaling. Upon binding its membrane-bound ligand (either Delta or Jagged), the Notch receptor undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by gamma-secretase. The second cleavage event releases the Notch intracellular domain (NICD), which subsequently translocates into the nucleus, heterodimerizes with the DNA-binding protein RBP-J, recruits co-activator molecules, and ultimately activates transcription. Notch 1 is expressed on thymocytes, bone marrow hematopoietic stem cells, T and NK cells. Lower Notch1 expression levels can be found on B cells and monocytes. Studies show that some subsets of T-cell acute lymphoblastic leukemia (T-ALL) arise due to Notch1 chromosomal translocation with TCRbeta, which results in the expression of constitutively active Notch1. This cell surface receptor is involved in T cell lineage commitment, thymocyte development, and Th2 differentiation. Applications Reported: This 22E5 antibody has been reported for use in flow cytometric analysis.
NOTCH1 Monoclonal antibody specifically detects NOTCH1 in Mouse samples. It is validated for Flow Cytometry.Specifications
22E5 | |
Flow Cytometry | |
APC | |
Rat | |
Mouse | |
18128 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
0.2 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
Q01705 | |
Notch1 | |
Primary | |
4° C, store in dark, DO NOT FREEZE! | |
Notch1 |
For Research Use Only.