Invitrogen™ NOSIP Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA584532

Product Code. 16331485

Description

Immunogen sequence: VCAVTRDSLS NATPCAVLRP SGAVVTLECV EKLIRKDMVD PVTGDKLTDR DIIVLQRGGT GFAGSGVKLQ AEKSRPVM Highest antigen sequence indentity to the following orthologs: Mouse - 95%, Rat - 95%.

NEDD4L is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. NEDD4L inhibits TGF-beta signaling by triggering SMAD2 and TGFR1 ubiquitination and proteasome-dependent degradation. NEDD4L promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1. 2, Nav1. 3, Nav1. 5, Nav1. 7, Nav1. 8, Kv1. 3, EAAT1 or CLC5. NEDD4L also promotes ubiquitination and degradation of SGK.

Specifications

• Antigen: NOSIP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: NOSIP
• Gene Alias: 2310061K06Rik; CGI-25; E3 ubiquitin-protein ligase NOSIP; eNOS-interacting protein; nitric oxide synthase interacting protein; nitric oxide synthase-interacting protein; Nosip; RING-type E3 ubiquitin transferase NOSIP
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51070
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y314
• Gene Symbols: NOSIP
• Immunogen: Recombinant protein corresponding to Human NOSIP. Recombinant protein control fragment (Product #RP-105223).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG