Invitrogen™ Nogo-A Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA520366

Product Code. 12818552

Description

Despite its predicted molecular weight, NogoA typically migrates at 180kDa in an SDS-PAGE. A suggested positive control is mouse brain tissue lysate. PA5-20366 can be used with blocking peptide PEP-0480.

NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS, blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.

Specifications

• Antigen: Nogo-A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rtn4
• Gene Alias: 1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; Foocen; glut4 vesicle 20 kDa protein; GLUT4 vesicle 20kDa protein; Human NogoA; KIAA0886; mKIAA0886; mKIAA4153; My043; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NgA; NI220/250; NI-220/250; NI-250; Nogo; Nogo protein; Nogo-A; Nogo-B; NOGOC; Nogo-C; NSP; NSP-CL; r; rat N; rat NogoA; reticulon 4; reticulon 5; reticulon-4; Reticulon-5; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; RTN-x; SP1507; Vp20
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57142, 68585, 83765
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q99P72, Q9JK11, Q9NQC3
• Gene Symbols: Rtn4
• Immunogen: A 23 amino acid peptide from near the amino terminus of human NogoA.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG